LymphedemaV1, Main, Exploration, bibRecord, 000505

Identification of sentinel lymph nodes by contrast‐enhanced ultrasonography with Sonazoid in patients with breast cancer: a feasibility study in three hospitals

Identifieur interne : 000505 ( Main/Exploration ); précédent : 000504; suivant : 000506

Identification of sentinel lymph nodes by contrast‐enhanced ultrasonography with Sonazoid in patients with breast cancer: a feasibility study in three hospitals

Auteurs : Kenzo Shimazu ; Toshikazu Ito ; Kumiko Uji ; Tomohiro Miyake ; Toyokazu Aono ; Kazuyoshi Motomura ; Yasuto Naoi ; Atsushi Shimomura ; Masafumi Shimoda ; Naofumi Kagara ; Seung Jin Kim ; Shinzaburo Noguchi

Source :

Cancer Medicine [ 2045-7634 ] ; 2017.

RBID : PMC:5548878

Abstract

The aim of this prospective study was to evaluate the feasibility of periareolar injection of the contrast agent Sonazoid (SNZ) followed by ultrasonography (US) for the identification of sentinel lymph node (SLN) in breast cancer patients with clinically negative node. Patients (n = 100) with T1‐2N0M0 breast cancer received a periareolar injection of SNZ followed by US to identify contrast‐enhanced SLN. Each contrast‐enhanced SLN underwent fine needle aspiration cytology (FNAC) followed by SLN biopsy with a conventional method using blue dye and/or radiocolloid (B/R). In almost all cases, contrast‐enhanced lymphatic vessels were clearly visualized by US soon after the periareolar injection of SNZ and the SLNs were easily identified with an identification rate of 98% (98/100) for SNZ and 100% (100/100) for B/R. The number of SLNs identified by SNZ (SNZ‐SLN) (mean per patient, 1.52) was significantly lower than that identified by B/R (B/R‐SLN) (2.19) (P < 0.0001). Twenty‐five patients with positive SLNs had at least one positive SNZ‐SLN. On a node‐by‐node basis, sensitivity, specificity, and accuracy of FNAC for SNZ‐SLNs (n = 149) were 33.3%, 99.2%, and 85.9%, respectively. Identification of SLN by periareolar injection of SNZ is a technically simple method with an identification rate as high as 98%. SNZ‐SLN thus seems to be a good target for FNAC, but sensitivity of FNAC for SNZ‐SLNs needs to be improved.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548878

DOI: 10.1002/cam4.1142
PubMed: 28766883
PubMed Central: 5548878

Affiliations:

Le document en format XML

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<author><name sortKey="Shimazu, Kenzo" sort="Shimazu, Kenzo" uniqKey="Shimazu K" first="Kenzo" last="Shimazu">Kenzo Shimazu</name>
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<author><name sortKey="Ito, Toshikazu" sort="Ito, Toshikazu" uniqKey="Ito T" first="Toshikazu" last="Ito">Toshikazu Ito</name>
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<author><name sortKey="Uji, Kumiko" sort="Uji, Kumiko" uniqKey="Uji K" first="Kumiko" last="Uji">Kumiko Uji</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of sentinel lymph nodes by contrast‐enhanced ultrasonography with Sonazoid in patients with breast cancer: a feasibility study in three hospitals</title>
<author><name sortKey="Shimazu, Kenzo" sort="Shimazu, Kenzo" uniqKey="Shimazu K" first="Kenzo" last="Shimazu">Kenzo Shimazu</name>
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<author><name sortKey="Kim, Seung Jin" sort="Kim, Seung Jin" uniqKey="Kim S" first="Seung Jin" last="Kim">Seung Jin Kim</name>
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<author><name sortKey="Noguchi, Shinzaburo" sort="Noguchi, Shinzaburo" uniqKey="Noguchi S" first="Shinzaburo" last="Noguchi">Shinzaburo Noguchi</name>
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<series><title level="j">Cancer Medicine</title>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>The aim of this prospective study was to evaluate the feasibility of periareolar injection of the contrast agent Sonazoid (<styled-content style="fixed-case">SNZ</styled-content>
) followed by ultrasonography (<styled-content style="fixed-case">US</styled-content>
) for the identification of sentinel lymph node (<styled-content style="fixed-case">SLN</styled-content>
) in breast cancer patients with clinically negative node. Patients (<italic>n</italic>
 = 100) with T1‐2N0M0 breast cancer received a periareolar injection of <styled-content style="fixed-case">SNZ</styled-content>
 followed by <styled-content style="fixed-case">US</styled-content>
 to identify contrast‐enhanced <styled-content style="fixed-case">SLN</styled-content>
. Each contrast‐enhanced <styled-content style="fixed-case">SLN</styled-content>
 underwent fine needle aspiration cytology (<styled-content style="fixed-case">FNAC</styled-content>
) followed by <styled-content style="fixed-case">SLN</styled-content>
 biopsy with a conventional method using blue dye and/or radiocolloid (B/R). In almost all cases, contrast‐enhanced lymphatic vessels were clearly visualized by <styled-content style="fixed-case">US</styled-content>
 soon after the periareolar injection of <styled-content style="fixed-case">SNZ</styled-content>
 and the <styled-content style="fixed-case">SLN</styled-content>
s were easily identified with an identification rate of 98% (98/100) for <styled-content style="fixed-case">SNZ</styled-content>
 and 100% (100/100) for B/R. The number of <styled-content style="fixed-case">SLN</styled-content>
s identified by <styled-content style="fixed-case">SNZ</styled-content>
 (<styled-content style="fixed-case">SNZ</styled-content>
‐<styled-content style="fixed-case">SLN</styled-content>
) (mean per patient, 1.52) was significantly lower than that identified by B/R (B/R‐<styled-content style="fixed-case">SLN</styled-content>
) (2.19) (<italic>P</italic>
 < 0.0001). Twenty‐five patients with positive <styled-content style="fixed-case">SLN</styled-content>
s had at least one positive <styled-content style="fixed-case">SNZ</styled-content>
‐<styled-content style="fixed-case">SLN</styled-content>
. On a node‐by‐node basis, sensitivity, specificity, and accuracy of <styled-content style="fixed-case">FNAC</styled-content>
 for <styled-content style="fixed-case">SNZ</styled-content>
‐<styled-content style="fixed-case">SLN</styled-content>
s (<italic>n</italic>
 = 149) were 33.3%, 99.2%, and 85.9%, respectively. Identification of <styled-content style="fixed-case">SLN</styled-content>
 by periareolar injection of <styled-content style="fixed-case">SNZ</styled-content>
 is a technically simple method with an identification rate as high as 98%. <styled-content style="fixed-case">SNZ</styled-content>
‐<styled-content style="fixed-case">SLN</styled-content>
 thus seems to be a good target for <styled-content style="fixed-case">FNAC</styled-content>
, but sensitivity of <styled-content style="fixed-case">FNAC</styled-content>
 for <styled-content style="fixed-case">SNZ</styled-content>
‐<styled-content style="fixed-case">SLN</styled-content>
s needs to be improved.</p>
</div>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Aono, Toyokazu" sort="Aono, Toyokazu" uniqKey="Aono T" first="Toyokazu" last="Aono">Toyokazu Aono</name>
<name sortKey="Ito, Toshikazu" sort="Ito, Toshikazu" uniqKey="Ito T" first="Toshikazu" last="Ito">Toshikazu Ito</name>
<name sortKey="Kagara, Naofumi" sort="Kagara, Naofumi" uniqKey="Kagara N" first="Naofumi" last="Kagara">Naofumi Kagara</name>
<name sortKey="Kim, Seung Jin" sort="Kim, Seung Jin" uniqKey="Kim S" first="Seung Jin" last="Kim">Seung Jin Kim</name>
<name sortKey="Miyake, Tomohiro" sort="Miyake, Tomohiro" uniqKey="Miyake T" first="Tomohiro" last="Miyake">Tomohiro Miyake</name>
<name sortKey="Motomura, Kazuyoshi" sort="Motomura, Kazuyoshi" uniqKey="Motomura K" first="Kazuyoshi" last="Motomura">Kazuyoshi Motomura</name>
<name sortKey="Naoi, Yasuto" sort="Naoi, Yasuto" uniqKey="Naoi Y" first="Yasuto" last="Naoi">Yasuto Naoi</name>
<name sortKey="Noguchi, Shinzaburo" sort="Noguchi, Shinzaburo" uniqKey="Noguchi S" first="Shinzaburo" last="Noguchi">Shinzaburo Noguchi</name>
<name sortKey="Shimazu, Kenzo" sort="Shimazu, Kenzo" uniqKey="Shimazu K" first="Kenzo" last="Shimazu">Kenzo Shimazu</name>
<name sortKey="Shimoda, Masafumi" sort="Shimoda, Masafumi" uniqKey="Shimoda M" first="Masafumi" last="Shimoda">Masafumi Shimoda</name>
<name sortKey="Shimomura, Atsushi" sort="Shimomura, Atsushi" uniqKey="Shimomura A" first="Atsushi" last="Shimomura">Atsushi Shimomura</name>
<name sortKey="Uji, Kumiko" sort="Uji, Kumiko" uniqKey="Uji K" first="Kumiko" last="Uji">Kumiko Uji</name>
</noCountry>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur le lymphœdème

Identification of sentinel lymph nodes by contrast‐enhanced ultrasonography with Sonazoid in patients with breast cancer: a feasibility study in three hospitals

Identification of sentinel lymph nodes by contrast‐enhanced ultrasonography with Sonazoid in patients with breast cancer: a feasibility study in three hospitals

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Abstract

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	Serveur d'exploration sur le lymphœdème
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